Uvavanyo lwegazi lunokunceda ekufumaneni umhlaza webele, utsho ukuFunda kwangoku

Amagama Aphezulu Ebantwaneni

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Umhlaza webele lolona hlobo luqhelekileyo lomhlaza ongelolusu. Kuthiwa yenye yeentlobo zomhlaza ezixhaphakileyo ebantwini, ngakumbi kule minyaka ilishumi idlulileyo. E-Indiya yodwa, zingaphezulu kwesigidi esinye isigulo somhlaza wamabele esixelwa minyaka le.

Ngokwengxelo yakutshanje, malunga ne-252, 710 yokufunyaniswa kwesifo kulindeleke kwabasetyhini, kwaye malunga ne-40,610 yabasetyhini banokufa kwesi sifo. Umhlaza webele ayikhethi bodwa kwabasetyhini, njengoko inokuchaphazela namadoda. Ngaphezulu kwe-9,500 yabantu abafuna ukhathalelo lomhlaza wamabele unyaka nonyaka kwaye phantse abantu abayi-1,500 bafumana utyando lomhlaza wamabele unyaka nonyaka ^[1] .

Umhlaza wamabele ukhula xa iiseli zamabele ziqala ukukhula ngokungaqhelekanga, eziphindaphindayo ngokukhawuleza kuneeseli ezisempilweni kwaye ziqhubeke nokuphindaphindeka, zikhokelela kuphuhliso lobunzima okanye iqhuma ^[Mbini] . Ngokwesiqhelo, kuye kwafunyanwa umhlaza wamabele xa kuvela uphawu okanye uphawu kwaye kuvavanywa ngoncedo lweemvavanyo kunye neenkqubo ezinje ngovavanyo lwebele, yovavanyo , ibele i-ultrasound njl.

Nangona kunjalo, uphononongo lwakutsha nje luthi uvavanyo lwegazi olunokunceda ekufumaneni umhlaza wamabele kwangoko.

Uvavanyo lweGazi lunokunceda ukufumanisa umhlaza webele kwiminyaka emi-5 ngaphambi kweempawu ezibonakalayo

Enye yeengozi ezinkulu kunye neengxaki xa kuziwa kumhlaza kukufumanisa ngokukhawuleza. Nje ukuba imeko isasazeke kwezinye iindawo, inqanaba lokusinda liphantsi kakhulu kwaye linokubakho kwakhona ^[3] .

Nangona kunjalo, ukufumanisa kwangoko kunye nonyango olusebenzayo kunokunceda ukuphucula izinga lokusweleka. Kodwa kwimeko yomhlaza wamabele, ukubhaqwa kwendalo kwasekuqaleni kunqunyelwe njengoko kungasoloko kuvelisa iimpawu ezibonakalayo kwinqanaba lokuqala, elinokukhokelela ekufumanekeni kade okunokuchaphazela ukusebenza konyango.

Kuphononongo lwakutsha nje oluqhutywe ngabaphandi baseYunivesithi yaseNottingham e-United Kingdom bathi uvavanyo lwegazi olukhangela ubukho beentsholongwane ezithile lunokunceda ekufumaneni umhlaza wamabele kwangoko kwaye ngokulula ^[4] .

Uvavanyo lunokufumana ii-Autoantibodies

Abaphandi baqhubeke bachaza indlela yovavanyo lwegazi ngokuchaza ukuba xa umhlaza ukho, umzimba wakho uvelisa iiantigen ezibangela ukuphendula komzimba. Oku, kubangela ukuba amajoni omzimba asabele kwizinto ngokukhupha ii-autoantibodies, eziya kuthi ke zifumaneke kuvavanyo lwegazi kwaye zibonise ukuba umhlaza wamabele ukhona okanye awukho.

Ekuqaleni, abaphandi bavelisa iipaneli ze-antigen ezinxulumene nethumba (TAAs) ezithile kumhlaza webele owanceda ekuqondeni ubukho be-autoantigen egazini elinxulunyaniswa nokuphendula komhlaza webele okhethekileyo we-TAAs ^[5] .

Omnye wabaphandi uDaniyah Alfattani uthe, 'Iziphumo zophononongo lwethu zibonise ukuba umhlaza wamabele ubangela ukuba ii-autoantibodies zichasene neepaneli ze-antigen ezithile ezinxulumene nethumba. Sikwazile ukufumanisa umhlaza ngokuchaneka okufanelekileyo ngokuchonga ii-autoantibodies ezisegazini ', kwaye sikwagxininisile kwisidingo sokuphuhlisa kunye nokuqinisekisa ngakumbi uvavanyo lwegazi ^[6] .

Ufundo lubonisa iziphumo ezithembisayo

Abaphandi bonwabile ziziphumo zophononongo kuba iziphumo ziyakhuthaza kwaye zibonisa ukuba kunokwenzeka ukufumana umqondiso womhlaza wamabele kwangoko. 'Nje ukuba siphucule ukuchaneka kovavanyo, emva koko ivule ithuba lokusebenzisa uvavanyo lwegazi olulula ukuphucula ukubonwa kwesi sifo kwangoko, utshilo umphandi ngokuqinisekileyo ^[6] .

Ngophando olunabaphenduli abangaphezulu kwama-90, kunokucingelwa ukuba iziphumo zichanekile ngokufanelekileyo kwaye uvavanyo lwegazi olunokutsha lunokuba luncedo ekuncedeni iingcali zonyango kunye noogqirha babone ubukho bomhlaza webele ukuya kuthi ga kwiminyaka emi-5 ngaphambi kokuba kuvele naziphi na iimpawu ezibonakalayo.

Kwinqaku lokugqibela ...

Ngophando oluvelisa iziphumo ezincumisayo, abaphandi bazimisele ukwandisa indawo yokufunda kuba uvavanyo lwegazi lokufumanisa umhlaza webele kwangoko luya kuba nendleko, kwaye luya kuba luncedo kunye neendlela ezilula zovavanyo xa kuthelekiswa amanyathelo akhoyo ^[7] . Uvavanyo olufanayo luyaphuhliswa kolunye uhlobo lomhlaza, kubandakanya imiphunga, ipancreatic, umbala omnyama kunye nomhlaza wesibindi.

1. [1]U-Lauren, S. & Cassell, M. Utyando lwebele, Isibhedlele iLenox Hill, isiXeko saseNew York City Amapolisa, MD, umphathi wengingqi waseWestchester, uqhaqho lwebele, iZiko loMhlaza lezeMpilo eNorthwell, Sleepy Hollow, NY NCRI (National Cancer Research Institute, UK), Ukukhululwa kweendaba, eyeNkanga 2, 2019
2. [Mbini]Spadafora, C., Sciamanna, I., De Luca, C., Sinibaldi-vallebona, P., Guadagni, F., Schumann, G., & Garaci, E. (2019). IU.S. Isicelo selungelo elilodwa lomenzi wechiza 15 / 564,089.
3. [3]Spadafora, C., Sciamanna, I., De Luca, C., Sinibaldi-Vallebona, P., Guadagni, F., Schumann, G., & Garaci, E. (2019). IU.S. Isicelo selungelo elilodwa lomenzi wechiza 10 / 214,591.
4. [4]UYadav, S., Kashaninejad, N., Masud, M. K., Yamauchi, Y., Nguyen, N., kunye noShiddiky, M. J. (2019). I-Autoantibodies njenge-diagnostic and prognostic cancer biomarker: Iindlela zokufumanisa kunye neendlela. I-Biosensors kunye ne-Bioelectronics, i-111315.
5. [5]Jiang, XH, Yao, Z.Y., He, X., Zhang, J. B., Xie, K., Chen, J., ... kunye no-Yie, S. M. (2019). Ukubaluleka kweklinikhi kwe-anti-TOPO48 ye-autoantibody kunye negazi elisindileyo-elibonisa ukujikeleza kweeseli zomhlaza kwizigulana ezinamanqanaba okuqala e-endometrial carcinoma. Oovimba be-gynecology kunye ne-obstetrics, i-299 (1), 229-237.
6. [6]USeluk, L., Taliansky, A., Yonath, H., Gilburd, B., Amital, H., Shoenfeld, Y., kunye noKivity, S. (2019). Isikrini esikhulu separaneoplastic neurological autoantibodies diagnostic kunye namaxabiso okuqikelela. I-Clinical Immunology, 199, 29-36.
7. [7]Khayeka-Wandabwa, C., Ma, X., Cao, X., Nunna, V., Pathak, J. L., Bernhardt, R., ... & Bureik, M. (2019). Ubume beplasma ulwazelelo lwasekhaya lwe-CYP4Z1 kunye ne-CYP19A1 kunye nokufunyanwa kwe-anti-CYP19A1 autoantibodies ebantwini. I-immunopharmacology yamanye amazwe, 73, 64-71.

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