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Ungaphoswa

Ekhaya Impilo Ukuphazamiseka kunyango Ukuphazamiseka kunyanga i-oi-Neha Ghosh Ngu UNeha Ghosh Nge-4 ka-Epreli 2019

IVitiligo yimeko yokuzimela komzimba apho amabala amhlophe akhula khona kulusu. E-India, izehlo ze vitiligo zivela kwi-0.25 ukuya kwi-2.5%. IRajasthan kunye neGujarat zezona zixhaphakileyo kule meko ^[1] .

Yintoni iVitiligo?

I-Melanocytes, iiseli ezenza i-pigment yesikhumba, zinoxanduva lombala wesikhumba, umbala wamehlo kunye nombala weenwele. Xa ii-melanocytes zitshatyalalisiwe, amabala amhlophe enza ulusu, eyaziwa ngokuba yi-vitiligo ^[Mbini] . IVitiligo ichaphazela ezinye iindawo zomzimba njengezandla, ubuso, intamo, amadolo, iinyawo neengqiniba.

IVitiligo ayosuleli kwaye sisiphumo sezinto zemfuza, izinto zokusingqongileyo okanye ukusilela kwizakhamzimba ezithile.

Umqondiso wokuqala we-vitiligo sisiqwenga esibonakala kancinci kwindawo yolusu kunye neenwele ezijika zimhlophe. Eminye imiqondiso kukwenziwa mhlophe phambi kwexesha kwentloko yakho, amashiya, iindevu kunye neenkophe, ukulahleka kombala kwizicwili ezihambelana nomlomo kunye nomlomo wakho, kunye nokulahleka kombala kwi-retina.

Unyango lwe-vitiligo luthatha ixesha ukubonisa iziphumo ezincumisayo. Nokuba yonyango oluqhelekileyo okanye lwendalo, kungathatha iinyanga ezi-6 ukuya kwiminyaka emibini.

Ukususela kumaxesha amandulo, iintlobo ezahlukeneyo zemifuno bezisetyenziselwa unyango lwe-vitiligo.

Unyango lweNdalo eli-10 lokuNyanga iVitiligo

1. UGinkgo biloba

Kule minyaka imbalwa idlulileyo, isicatshulwa se-ginkgo biloba sisetyenziselwe unyango lwe-vitiligo kuba i-ginkgo biloba inezinto ezichasene nokuvuvukala, i-immunomodulatory, kunye ne-antioxidant. Idatha yophando ibonisa ukuba i-ginkgo biloba ilawula ukusebenza kwe-vitiligo kwaye inyanzelisa ukubekwa ngokutsha kweemacule ezimhlophe ukuba zisetyenziswe kwezinye iindlela zonyango ezinje ngeefototherapies kunye ne-corticosteroids ^[3] . Olunye uphononongo lukwabonisa ukusebenza kwesicatshulwa semifuno xa silawulwa sodwa ^[4] .

Iziphumo zokumiselwa ngokutsha zinokwahluka ngokuxhomekeka kwizinto ezifana ne-ginkgo biloba extracts, ixesha lonyango, kunye nenani leedosi ngemini.

Iyeza lenziwe kwithebhulethi kwaye idosi yemihla ngemihla iyi-120 mg ngosuku. Kufuneka ithathwe ngomlomo kube kanye ukuya kathathu yonke imihla ngaphezulu kweenyanga ezintathu.

2. Isiphithiphithi

I-Turmeric iqulethe i-polyphenol compound ebizwa ngokuba yi-curcumin eyaziwayo ukuba iqulethe i-antioxidant, anti-inflammatory, antiviral, antibacterial, antiproliferative kunye ne-antifungal. Ngokophando lwakutsha nje, kusetyenziswe i-tetrahydrocurcumide cream nge-nb-UVB kunyango lwe-vitiligo kwaye iziphumo zibonise ukubuyiselwa okuhle ^[5] .

3. Iti eluhlaza

Amagqabi eti eluhlaza atyebile kwii-polyphenol antioxidants. Izicatshulwa zegqabi leti eluhlaza zisebenza njenge-anti-inflammatory, antioxidant, kunye ne-immunomodulatory agents ezibonakaliswe ziluncedo kunyango lwe-vitiligo ngokumisa uxinzelelo lwe-oxidative yeyunithi ye-melanocyte ^[6] .

Isicatshulwa segqabi leti eluhlaza sinokulawulwa ngomlomo nangokwezihloko.

4. ICapsaicin

Ipelepele iChilli iqulathe ikhompawundi esebenzayo ebizwa ngokuba yi-capsaicin equlathe iipropathi zokulwa nokudumba ezisebenza njengonyango lwonyango lwe-vitiligo ^[7] .

5. Ikhala vera

I-Aloe vera inokunyanga izifo ezahlukeneyo zolusu kubandakanya ukuphazamiseka kombala kuba inezakha mzimba iivithamini ezinjengevithamini A, ivithamin C, ivithamini B12 kunye nefolic acid. Isicatshulwa se-Aloe vera sine-zinc, ubhedu, kunye ne-chromium enokuxhasa ukuphindaphinda kolusu ^[8] .

Ukukhupha ijeli kwigqabi le-aloe vera kwaye uyisebenzise kwindawo echaphazelekayo.

6. IMuskmelon

Isicatshulwa seMuskmelon sipakishwe sigcwele ii-antioxidants ezithintela ulwakhiwo lwe-melanocytes olubangelwa luxinzelelo lwe-oxidative. Uphononongo lubonise ukusebenza kokuqulunqwa kwejeli equkethe i-phenylalanine, i-muskmelon extract, kunye ne-acetylcysteine in vitiligo. Unyango luqhubekile kwiiveki ezili-12 kwaye iipesenti ezingama-75 zokumiselwa kwakhona kubonisiwe kwizigulana ^[9] .

7. I-Picrorhiza kurroa

I-Picrorhiza kurroa, ekwabizwa ngokuba yi-kutki okanye i-kutaki, sisityalo sonyango esifumaneka kwiiHimalaya. Iqukethe iipropati zokukhusela i-hepatoprotective, antioxidant kunye ne-immunomodulatory. Isifundo sibonise amandla ePicrorhiza kurroa asetyenziswa kunye nefototherapy kunyango lwe-vitiligo. Yayilawulwa kabini ngemini ngomlomo kangangeenyanga ezi-3 ^[10] .

8. IPyrostegia Venusta

I-Pyrostegia venusta yimifuno esetyenziselwa unyango lwe-vitiligo. Iqulethe iipropathi antioxidant, anti-ukudumba kunye melanogenic. Ifunyenwe kwiBrazil esemaZantsi, apho kusetyenziswa imixube engamayeza ekunyangeni i-vitiligo ^{[Shumi elinanye]} .

9. UKhellin

Ukusukela kumaxesha amandulo ase-Egypt, i-khellin ibisetyenziswa njengeyeza lesintu kunyango lwezifo ezininzi ezinjengezintso, isifo sentliziyo, i-vitiligo, i-asthma ye-bronchial kunye ne-psoriasis. I-Khellin esetyenzisiweyo kunye ne-UVA phototherapy ibonakalisiwe iyasebenza kunyango lwe vitiligo. UKhellin usebenza ngokukhuthaza ukwanda kwe-melanocytes kunye ne-melanogenesis ^[12] .

10. I-Polypodium leucotomos

I-Polypodium leucotomos yifern tropical ekhoyo ngohlobo lwee-capsules kunye ne-cream ye-topical. Ifumaneka kwimimandla yetropiki nakwindawo ezitshisayo zaseMelika. Izicatshulwa zepolypodium leucotomos ziyaziwa ngokudibanisa iipropathi zokulwa ne-antioxidant kunye ne-photoprotective kwaye zisetyenziselwa unyango lwezifo ezahlukeneyo zolusu. I-polypodium leucotomos isetyenzisiwe kunye ne-phototherapy kwizigulana ze-vitiligo ^[13] .

Phawula: Ngaphambi kokusebenzisa la mayeza emvelo, kungcono ukuba ubonane nogqirha malunga nedosi efanelekileyo kunye nokusetyenziswa okufanelekileyo njengoko kunokuba neziphumo ebezingalindelekanga ongazaziyo.

Jonga iZalathiso zeNqaku

[1]IVora, R. V., Patel, B. B., Chaudhary, A.H, Mehta, M. J., kunye nePilani, A. P. (2014). Isifundo seKlinikhi seVitiligo kwindawo esemaPhandleni yaseGujarat. Ijenali yaseIndiya yamayeza oluntu: upapasho olusemthethweni loMbutho waseIndiya woNyango kunye noNyango lwezeNtlalo, i-39 (3), 143-146.
[Mbini]IYamaguchi, Y., kunye nokuva, V. J. (2014). Melanocytes kunye nezifo zabo. Iimbono zeCold Spring Harbour kwezonyango, 4 (5), a017046.
[3]UCohen, B. E., Elbuluk, N., Mu, E. W., kunye no-Orlow, S. J. (2015). Olunye unyango lwenkqubo ye-vitiligo: uphononongo. Ijenali yaseMelika yedermatology yeklinikhi, 16 (6), 463-474.
[4]IParsad, D., uPandhi, R., noJunija, A. (2003). Ukusebenza kwe-Ginkgo biloba yomlomo kunyango oluncinci, olusasazekayo lwe-vitiligo.Clinical and Testing Dermatology: Uvavanyo lwedermatology, 28 (3), 285-287.
[5]UAsawanonda, P., kunye noKlahan, S. O. (2010). I-Tetrahydrocurcuminoid cream kunye ne-targetband ye-UVB phototherapy ye-vitiligo: isifundo sokuqala esilawulwa ngokungahleliwe. I-Photomedicine kunye ne-laser, 28 (5), 679-684.
[6]Jeong, Y. M., Choi, Y. G., Kim, D. S., Park, S. H., Yoon, J. A., Kwon, S. B., ... & Ipaki, K. C. (2005). Isiphumo seCytoprotective sokukhutshwa kweti eluhlaza kunye nequercetin ngokuchasene noxinzelelo lwe-hydrogen peroxide-indased oxidative.Izinto zokugcina uphando lwe-pharmacal, 28 (11), 1251.
[7]Becatti, M., Prignano, F., Fiorillo, C., Pescitelli, L., Nassi, P., Lotti, T., kunye noTaddei, N. (2010). Ukubandakanyeka kwe-Smac / i-DIABLO, i-p53, i-NF-kB, kunye ne-MAPK yeendlela kwi-apoptosis ye-keratinocyte ukusuka kulusu lwe-vitiligo yesikhumba: Iziphumo zokukhusela i-curcumin kunye ne-capsaicin.
[8]I-Tabassum, N., kunye neHamdani, M. (2014). Izityalo ezisetyenziselwa ukunyanga izifo zolusu. UPhononongo lwePharmacognosy, 8 (15), 52-60
[9]IBuggiani, G., Tsampau, D., Hercogovà, J., Rossi, R., Brazzini, B., kunye neLotti, T. (2012). Ukusebenza klinikhi kokuveliswa kwentloko ye-vitiligo: ukuthelekiswa kovavanyo lweendlela ezahlukeneyo zonyango kwizigulana ze-149 Unyango lweDermatologic, 25 (5), 472-476.
[10]UGianfaldoni, S., Wollina, U., Tirant, M., Chernev, G., Lotti, J., Satolli, F.,… Lotti, T. (2018). Iimpawu zeHerbal zoNyango lweVitiligo: uphononongo oluVulekileyo lokufikelela kwiphephancwadi laseMakedoni lezenzululwazi zonyango, i-6 (1), 203-207.
[Shumi elinanye]UMoreira, C. G., Carrenho, L. Z. B., Pawloski, P. L., Soley, B. S., Cabrini, D. A., kunye no-Otuki, M. F. (2015). Ubungqina bangaphambi kweklinikhi yePyrostegia venusta kunyango lwe-vitiligo. Ijenali ye-ethnopharmacology, 168, 315-325.
[12]UCarlie, G., uNtusi, uN. B., uHulley, uPA, noKidson, uSH (2003). I-KUVA (khellin kunye ne-ultraviolet A) ivuselela ukwanda kunye ne-melanogenesis kwi-melanocytes eqhelekileyo yomntu kunye neeseli ze-melanoma kwi-vitro. Ijenali yaseBritane yeDermatology, 149 (4), 707-717.
[13]UNestor, M., Bucay, V., uCallender, V., uCohen, uJ. L., uSadick, uN., NoWaldorf, uH (2014). I-polypodium leucotomos njengoNyango oluHlangeneyo lweNgxaki zePigmentary Journal ye-dermatology yeklinikhi kunye nobuhle, 7 (3), 13-17.