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Izinto ezinobungozi ezivelayo ze-COVID-19 zibandakanya ubudala, isini, uxinzelelo lwegazi, isifo seswekile kunye nokutyeba kakhulu. Kutshanje, ubungqina bezonyango kunye nezifundo ziphakamise unxibelelwano olunokubakho phakathi kwePCOS kunye ne-COVID-19.
Izifundo zithi abasetyhini abanesifo se-polycystic ovary syndrome (i-PCOS) okanye i-polycystic ovarian isifo (i-PCOD) banokuba semngciphekweni wokosuleleka yi-COVID-19 xa kuthelekiswa nabasetyhini abangenayo i-PCOS. Eli nqaku liza kuxubusha ukuba kutheni kwaye kutheni kunokwenzeka. Funda ukuze wazi ngakumbi.
I-COVID-19 kunye nabafazi ababandezeleka kwi-PCOS
Ngokophando olupapashwe kwiJenali yaseYurophu ye-Endocrinology, abasetyhini abane-PCOS bakwiipesenti ezingama-28 ukonyuka komngcipheko wokosulelwa yi-COVID-19 xa kuthelekiswa nabasetyhini abangenale meko. Iziphumo zabalwa emva kokuhlengahlengisa iminyaka, i-BMI kunye nomngcipheko wengozi. [1]
Ngaphandle kolu hlengahlengiso sele lukhankanyiwe, uhlalutyo lubonakalisile ukuba abasetyhini be-PCOS bakwiipesenti ezingama-51 kumngcipheko ophezulu we-COVID-19 phakathi kwabasetyhini ngaphandle kwePCOS.
Kutheni izigulana ze-PCOS zisengozini yokunyuka kwe-COVID-19?
Ukusukela namhlanje, i-COVID-19 ichaphazele abantu abayi-124 yezigidi kwihlabathi liphela, ngezigidi ezingama-70.1 ezifunyenweyo kunye nokusweleka kwezigidi eziyi-2.72. Izifundo ezininzi ezipapashiweyo zibonise ukuba iimeko ze-COVID-19 zaselebhu ezixhaphakileyo zixhaphake kakhulu kumadoda kumazwe aliqela xa kuthelekiswa nabasetyhini.
Nangona unobangela unemisebenzi emininzi, ifuthe lehomoni ye-androgen ithathwa njengesona sizathu siphambili somahluko okhethekileyo ngokwesini kwinqanaba losulelo.
I-Androgen ibhekiswa ikakhulu njengehomoni eyindoda elawula ukukhula kunye nokugcinwa kweempawu zamadoda kunye nemisebenzi yabo yokuzala. [Mbini]
Ihomoni ikhoyo kubo bobabini abesilisa nabasetyhini, kodwa owona msebenzi uphambili kukukhuthaza i-testosterone kunye ne-androstenedione, ezimbini kwiihomoni zesini zamadoda.
I-PCOS sisifo se-endocrine apho amanqanaba e-androgens (ihomoni yamadoda) inyuka, endaweni ye-estrogen (ihomoni yabasetyhini). Oku kukhokelela kwi-hyperandrogenism kunye nokungasebenzi kakuhle kwe-ovari, kubangele ukungachumi kwezinye ngaphandle kokuchongwa ngokufanelekileyo kunye nonyango.
Njengoko i-hormone ye-androgen ithathwa njengeyona nto iphambili kumngcipheko wosulelo lwe-COVID-19, kunokuthiwa abafazi be-PCOS banokuchaphazeleka ngakumbi kwesi sigulo, kuthathelwa ingqalelo ukuba ezinye izinto ezinje ngokutyeba kakhulu kwabasetyhini be-PCOS zinokuba ngunobangela.
Ezinye izinto
1. Ukuxhathisa kwe-insulin
I-PCOS inxulunyaniswa nokuphazamiseka komzimba njenge-insulin ukumelana nesifo seswekile. I-insulin yihomoni enceda ukulawula amanqanaba eglucose emzimbeni, kunye nokulawula imetabolism yeeproteni kunye neepids.
Ukuxhathisa kwe-insulin kuyaphuculwa xa umzimba ungaphenduli kwi-insulin, kubangela ukungasetyenziswa kweglucose egazini kumandla, kukhokelela ekwandeni kweglucose yegazi. Ukugqithisa kweswekile kuqala ukuphazamisa iiseli zomzimba ezinje ngeeseli ze-B, ii-macrophage kunye neeseli ze-T, oko kukhokelela ekwehleni kwemisebenzi yomzimba yokuzikhusela.
Ukungasebenzi kakuhle kwamajoni omzimba ngenxa yokuxhathisa kwe-insulin, eyaqala ngenxa ye-PCOS ekugqibeleni inokuthi kutheni abasetyhini abane-PCOS bachaphazeleka kakhulu yi-coronavirus. [3]
2. Ukutyeba ngokugqithiseleyo
Uphononongo lubonakalisile ukuba kwakamsinya emva kokuvela kwe-coronavirus, phakathi kwabantu ababenomoya, umyinge wezigulana ezityebe kakhulu wawuphezulu, kulandele ukonyuka kokubhubha kwaba bantu. [4]
Olunye uphononongo luye lwaqaqambisa into yokuba ngexesha lobhubhane lwe-H1N1 lwangaphambili okanye umkhuhlane weehagu, ubungqongqo bale meko babuphezulu kubantu abatyebe kakhulu. [5]
Malunga ne-38-88 yepesenti yabasetyhini abane-PCOS bafunyenwe betyebe kakhulu okanye batyebe kakhulu. Unxibelelwano olusondeleyo phakathi kokutyeba kakhulu, i-PCOS kunye ne-COVID-19 inokugqiba, ukuba abasetyhini be-PCOS banokuchaphazeleka kakhulu kwi-COVID-19 ngenxa yokutyeba kakhulu okanye ukutyeba kakhulu.
3. Ukuswela iVitamin D
Ukunqongophala kukaVitamin D kudityaniswa ne-PCOS kunye nosulelo lwe-COVID-19 ngeendlela ezininzi. I-Vitamin D yivithamini ebalulekileyo enokukunceda ukuthintela usulelo lokuphefumla lwe-COVID-19 yipropathi yayo yokunyusa amajoni omzimba kunye nokunciphisa ii-cytokines ezivuthayo ezikhokelela kwinyumoniya.
Malunga neepesenti ezingama-67-85 zabasetyhini abane-PCOS, ukusilela okuphezulu kwe-vitamin D kuye kwaqwalaselwa. [6]
Ukungabikho kwe-vitamin D kunokubangela ukungasebenzi komzimba, ukonyuka kwama-cytokines kunye nokunyuka komngcipheko wesifo seswekile, ukumelana ne-insulin kunye nokukhuluphala, zonke iingxaki ze-PCOS.
Ke ngoko kunokuthiwa ukusilela kwe-vitamin D kunokunxulunyaniswa ne-PCOS kunye nokunyusa iingxaki kunye nenqanaba lokufa ngenxa ye-COVID-19.
4. I-microbiota elungileyo
I-Gut dysbiosis okanye ukungasebenzi kakuhle kwe-gut microbiota kunxulunyaniswa neemeko zempilo ezinje nge-PCOS.
I-PCOS kunye nempilo yamathumbu iyahambelana. Abasetyhini abane-PCOS bahlala befumaneka nge-gut dysbiosis. Nangona kunjalo, ukuba amanqanaba eswekile alawulwa kakuhle kwaye inkqubo yokugaya ithathwa ikhathalelwe kwi-PCOS, impilo yamathumbu inokuphuculwa.
Utshintsho kulwakhiwo lwe-gut microbiome lunokuchaphazela amajoni omzimba, eyona nkqubo iphambili yomzimba esikhusela kwizifo kwaye ke, zisenze sithambekele kwizifo ezinje nge-COVID-19.
Ukusetyenziswa kweeprobiotic ukugcina ibhalansi ye-microbiota yamathumbu kunokunceda ukukhusela amajoni omzimba kunye nokuthintela umngcipheko we-COVID-19.
Ukushwankathela
Ukuxhathisa kwe-insulin kunokunyusa imveliso ye-androgens kwabasetyhini abane-PCOS. Ukutyeba kakhulu kunye nokutyeba kakhulu kunokubangela ukuxhathisa kwe-insulin kwaye ke, kuphucule imveliso ye-androgen. Oku kunokubangela ukungasebenzi kakuhle kwamajoni omzimba ngenxa ye-endocrine-immune axis, enokuthi emva koko inyuse umngcipheko we-COVID-19 kubafazi be-PCOS.
