L-carnitine: Izibonelelo zayo, oovimba kunye neziphumo ebezingalindelekanga

Amagama Aphezulu Ebantwaneni

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Umhla Wokuzalwa:

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I-L-carnitine yi-amino acid, eveliswa ngokwasemzimbeni emzimbeni. Isiphumo se-amino acid sisongezelelo esisetyenziswa rhoqo. Isondlo sidlala indima ebalulekileyo kwimveliso yamandla emzimbeni wakho. Ngokuhambisa ii-acid ezinamafutha emzimbeni wakho ukuya kwi-mitochondria, ethi yona incede ukutshisa amanqatha kwaye iwuguqule ube ngamandla.

I-L-carnitine iveliswa emzimbeni wakho, eveliswa yi-amino acid lysine kunye ne-methionine. Ukuze umzimba wakho uvelise ubungakanani obufunekayo be-L-carnitine, kufuneka ubenezixa ezifanelekileyo ze-vitamin C. Ngaphandle kwalonto, i-L-carnitine inokufumaneka ngexabiso elincinci ngokutya ukutya okufana nenyama, ubisi, intlanzi njlnjl. ikwafumaneka ngohlobo lwezongezelelo ^{[1] [Mbini]} .

I-amino acid yimo esemgangathweni esebenzayo ye-carnitine (igama eliqhelekileyo le-quaternary ammonium compound echaphazelekayo kwimetabolism kwizilwanyana, izityalo kunye nezinye iibhaktheriya), ezifumaneka kwi-D-carnitine, i-Acetyl-L-carnitine, Ipropionyl-L-carnitine, kunye ne-L-carnitine L-tartrate ^[3] .

Izibonelelo zezeMpilo ze-L-carnitine

1. Aids ukwehla kobunzima

U-L-carnitine uphakame waduma kumaxesha akutshanje kunye namandla akhe acetywayo okunceda ukunciphisa umzimba. Isongezelelo seamino acid sisebenza ngokuhambisa iiasidi ezinamafutha kwiiseli zakho, eziya kuthi emva koko zitshiswe zibe namandla. Nangona kubekho ukuphikisana nokubanakho kwesongezelelo sokukhuthaza ukunciphisa umzimba, isifundo esenziwe kubantu abatyebe kakhulu sixhasa ibango lokuba i-L-carnitine iyanceda ukuncipha ^[4] .

2. Ukuphucula ukusebenza kwengqondo

Olunye uphononongo lubonise ukuba i-L-carnitine inokunceda ukuphucula ukusebenza kwengqondo yakho. Oko kukuthi, kunokunceda ukuthintela ukwehla kwengqondo okunxulumene nobudala, kuncede ukuphucula amandla okufunda, kwaye kuncede ukubuyisela umva ukwehla kokusebenza kwengqondo kuthintela ukuqala kwe-Alzheimer's kunye nezinye izifo zobuchopho ^[5] .

3. Ulawula impilo yentliziyo

I-L-carnitine inxulunyaniswe nokunciphisa uxinzelelo lwegazi kunye nenkqubo yokuvuvukala ehambelana nesifo sentliziyo. Kuye kwaqinisekiswa ukuba banako ukuphucula imeko yabantu abaneengxaki zentliziyo ezinzulu, ezifana nesifo senhliziyo kunye nokuhluleka kwentliziyo engapheliyo. ^[6] .

4. Ukunyusa umgangatho wentsebenzo

Izifundo ezahlukeneyo zichaze izibonelelo, nangona zincinci, i-L-carnitine inayo ekuphuculeni ukusebenza komntu kwezemidlalo. Ngenxa yale propati, i-L-carnitine ligama eliqhelekileyo kwicandelo lezemidlalo. Inokukunceda ukuphucula ukubuyisa imithambo, yonyuse ukubonelela ngeoksijini kwimisipha yakho, iphucule amandla akho, ukunciphisa ukukhathazeka kwemisipha kunye nokwandisa imveliso yeeseli ebomvu. ^[3] .

5. Ukulawula isifo seswekile

I-L-carnitine inokukunceda ulawule kwaye unciphise iimpawu zeswekile, ngakumbi udidi lweswekile lwesibini. Kuyanceda ekulawuleni umngcipheko wale meko, njengoko iamino acid inokunceda ukunciphisa amanqanaba eswekile yegazi ^[6] .

Kukwathiwa kuluncedo ekuboneleleni ngesiqabu kwintlungu yesifuba, isifo sezintso, i-hyperthyroidism, ukungachumi kwamadoda, amabala, ukulahleka kweenwele, i-autism, ukubetha kwentliziyo okungaqhelekanga, imithambo evalekileyo, ukudinwa, ubunzima bokuzalwa obuphantsi kunye nezinye ezahlukeneyo. Nangona kunjalo, kukho ukunqongophala kwezifundo ekusetyenzisweni okwandisiweyo kunye nokusebenza kwe-L-carnitine kwiimeko ezahlukeneyo ^[7] .

Iziphumo ebezingalindelekanga ze-L-carnitine

I-L-carnitine yongeza okanye inaliti, nangona ikhuselekile ekusebenziseni umntu, inokubangela iziphumo ebezingalindelekanga kubantu abathile. Ezinye zeziphumo ebezingalindelekanga eziqhelekileyo zeamino acid zichaziwe apha ngezantsi ^[8] .

• Isicaphucaphu
• Ukuhlanza
• Intlungu yesisu
• Isitshisa
• Urhudo
• Ukuxhuzula
• Ivumba lentlanzi kumchamo, umphefumlo kunye nokubila

Ngaphandle kwalonto, abasetyhini abakhulelweyo nabancancisayo kufuneka bakuphephe ukusebenzisa i-L-carnitine ^[9] . Ukugqithisa kwe-L-carnitine kunokubangela ukungaphumeleli kwezintso, kunye nokubonakalisa iimpawu ze-hypothyroidism. Kwakhona, kunqande ukusebenzisa i-L-carnitine yokulawula ukuxhuzula, ukuba sele ukhe wahlupheka ngaphambili.

Umthamo we-L-carnitine

Qaphela: Kuya kufuneka ubonane nogqirha ngaphambi kokufaka izongezo ze-L-carnitine okanye inaliti kwimikhwa yakho.

Umthamo okhankanywe apha ngowabantu abadala ^[10] .

Ukusilela kwe-L-carnitine: 990 mg, kabini ukuya kathathu mihla le (iipilisi okanye isisombululo somlomo).

Intlungu yesifuba: 900 mg ukuya kwi-2 g kwi-1 ukuya kwi-2 idosi eyahluliweyo imihla ngemihla iiveki ezi-2 ukuya kwiinyanga ezi-6.

Idosi esemgangathweni ye-L-carnitine yi-500-2,000 mg ngosuku.

Kwinqaku lokugqibela ....

Kwiivenji, ukuvelisa kunye nokufumana i-L-carnitine akunakwenzeka ngenxa yokunqongophala kwenyama kunye nentlanzi. Kuyafana nakubantu abaphethwe yimicimbi ethile yemfuza. Nangona kunjalo, umntu unokufumana isixa esifunekayo se-L-carnitine ngokutya izongezo ze-L-carnitine.

1. [1]Intsimi, R., Riede, L., Lugo, J., kunye neBellamine, A. (2018). l-Carnitine supplementation ekubuyiseleni emva kokuzivocavoca. Izondlo, 10 (3), 349.
2. [Mbini]UKoeth, R. A., Lam-Galvez, B. R., Kirsop, J., Wang, Z., Levison, B. S., Gu, X., ... kunye noCulley, M.K (2018). l-I-Carnitine kwizidlo ezinomtsalane kwi-atherogenic gut microbial pathway ebantwini. Ijenali yoPhando lweKlinikhi, 129 (1), 373-387.
3. [3]INovakova, K., Kummer, O., Bouitbir, J., Stoffel, S. D., Hoerler-Koerner, U., Bodmer, M., ... kunye neKrähenbühl, S. (2016). Iziphumo zokuncedisa i-l-carnitine kumanzi echibini le-carnitine, amandla emethambo yemetabolism kunye nokusebenza komzimba kubantu abadla inyama. Ijenali yaseYurophu yesondlo, 55 (1), 207-217.
4. [4]U-Lee, B.J, uLin, uJ. S., uLin, uYC, noLin, uPT (2015). Iziphumo ezichaseneyo ne-L-carnitine supplementation (1000 mg / d) kwizigulana ze-coronary disease. Nutrition, 31 (3), 475-479.
5. [5]UChan, Y.L, Saad, S., Al-Odat, I., u-Oliver, uB. G., uPollock, uC., UJones, uN. M., noChen, uH (2017). Unyango lwe-L-carnitine yoomama luphucula impilo yengqondo kwinzala evela kumsi wecuba oomama abatyhilekileyo.Iifronti kwi-molecular neuroscience, 10, 33.
6. [6]UFukami, K., Yamagishi, S. I., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., ... & Okuda, S. (2015). Unyango lwe-Oral L-carnitine yonyusa i-trimethylamine-N-oxide kodwa inciphisa amanqaku okonzakala kwe-vascular kwizigulana ze-hemodialysis. Ijenali ye-pharmacology ye-cardiovascular, 65 (3), 289-295.
7. [7]UDa Silva, G. S., de Souza, C. W., da Silva, L., Maciel, G., Huguenin, A. B., de Carvalho, M., ... kunye neColafranceschi, A. (2017). Iziphumo zokuNcediswa kwe-L-Carnitine kuLungiso oluGuquliweyo kwizigulana ezinesifo sentliziyo esiyi-Ischemic Ukuthotyelwa kweCoronary Artery Bypass Grafting: Ityala elilawulwa ngokungahleliwe, elilawulwa yiPlacebo. Izikhuselo zesondlo kunye nemetabolism, 70 (2), 106.
8. [8]U-Lee, B. J., uLin, uJ. S., uLin, uYC, noLin, uPT (2016). Iziphumo zokongezwa kwe-L-carnitine kwiiprofayili ze-lipid kwizigulana ezinesifo semithambo. Iipipid kwimpilo nakwizifo, 15 (1), 107.
9. [9]UPala, R., Genc, ​​E., Tuzcu, M., Orhan, C., Sahin, N., Er, B., ... kunye neSahin, K. (2018). Ukongezwa kwe-L-Carnitine kukonyusa ukubonakaliswa kwe-PPAR-γ kunye nabathuthi be-glucose kwimisipha yemithambo yezigundane ezingapheliyo kunye neeselfowuni.
10. [10]Imbe, A., Tanimoto, K., Inaba, Y., Sakai, S., Shishikura, K., Imbe, H., ... & Hanafusa, T. (2018). Iziphumo zokuncedisa i-L-carnitine kumgangatho wobomi kwizigulana ezinesifo seswekile ezinezihlunu zemisipha. Ijenali ye-Endocrine, i-EJ17-0431.

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